EXPERT PROFILES
Course Module 1:RNA Biology
Professor Jerry L. Workman is a Senior Investigator at the prestigious Stowers Institute in the United States, a pioneering scientist and a member of the esteemed American Academy of Arts and Sciences. His exceptional contributions to gene expression research have reshaped the field, particularly in uncovering the pivotal role of histones in DNA packaging and gene regulation. His landmark discovery of diverse histone-modifying enzyme complexes has greatly enhanced our understanding of gene expression dynamics. Recognized for his outstanding achievements, Professor Workman received the Maximizing Investigator's Research Award from the National Institute of General Medical Sciences in 2018. His seminal work involved the identification of diverse histone- modifying enzyme complexes, which has since been regarded as a landmark discovery in the realm of gene expression studies. Jerry L. Workman's invaluable findings have greatly enhanced our understanding of the intricate mechanisms governing gene regulation. He received the Maximizing Investigator’Research Award 2018 from National Institute of General Medical Sciences.
Professor Dinshaw J. Patel is the member of the National Academy of Sciences and the American Academy of Arts and Sciences. He holds the Abby Rockefeller Mauzé Chair in Experimental Therapeutics at Memorial Sloan-Kettering Cancer Center (MSKCC) and serves as a faculty member in the Structural Biology Program at the Sloan-Kettering Institute (SKI). He has dedicated his career to investigating structure-based mechanistic insights underlying biological macromolecular interactions, including the CRISPR-Cas and cGAS-STING surveillance pathways, histone and DNA methylation in epigenetic regulation and RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways. His commitment to advancing scientific knowledge and fostering global partnerships in research has been acknowledged with awards such as the inaugural C.C. Tan Life Science International Collaboration Award.
Professor Don Cleveland is the member of the National Academy of Sciences and the American Academy of Arts and Sciences, the member of the American Association for the Advancement of Science. As a distinguished cancer biologist and neurobiologist, he currently serves as the dean of the Department of Cell and Molecular Medicine at the University of California, San Diego. In 2013, he was elected as the President of the American Society for Cell Biology. Recognized for his groundbreaking work, he was awarded the Life Science Breakthrough Award in 2018 for his pivotal research on elucidation of the molecular pathogenesis of hereditary ALS, including the role of glia in neurodegenerative diseases, and the establishment of antisense oligonucleotide therapy in animal models of ALS and Huntington's disease. His groundbreaking research contributions extend to the assembly of mitotic spindles and the regulation of chromosome movement.
Professor Shaorong Gao is a member of the Chinese academy of Sciences, serving as dean of the School of Life Science and Technology at Tongji University, and Director of the Frontier Science Center for Cell Stem. He is an world-renowned developmental and stem cell biologist. His primary research focuses on the molecular regulatory mechanisms in embryo development and somatic cell reprogramming. He successfully produced iPS mice, thereby demonstrating the pluripotency of iPS cells. He identified key mechanisms of epigenetic reprogramming in iPSC induction and somatic cell nuclear transfer. He has also successfully elucidated the dynamics and epigenetic regulatory mechanisms of DNA and histone modifications remodeling during early embryo development, making significant contributions to the advancement of stem cell and developmental biology.
Prof. Duojia Pan is a member of the American Academy of Sciences, he is currently Bashour Distinguished Chair of Physiology at UT Southwestern Medical Center, and an Investigator of the Howard Hughes Medical Institute. He received the Paul Marks Prize for Cancer Research and the Passano Award, and was elected as a fellow of the American Association for the Advancement of Science. Much of his work over the past 20 years has focused on the Hippo signaling pathway, a fundamental mechanism that regulates tissue growth in animals ranging from insects to mammals. His laboratory systematically decoded the key molecular events in the Hippo pathway in Drosophila and established its conserved role in mammalian tissue growth, regeneration and tumorigenesis. Besides the Hippo pathway, his laboratory also elucidated the molecular function of the Tsc1 and Tsc2 tumor suppressor genes, linking Tsc1/Tsc2 to Rheb and mTOR signaling. This work provided the molecular basis for the use of mTOR inhibitors in the treatment of Tuberous Sclerosis.
Professor Yanhui Xu’s a distinguished researcher renowned for his contributions to the field of gene expression regulation, the assembly of transcriptional initiation complexes, chromatin remodeling, and DNA methylation regulation. His groundbreaking work has earned widespread recognition and praise within the scientific community. With over 40 corresponding author papers to his name, including publications in prestigious journals such as Science, Nature, and Cell, Prof. Xu has demonstrated excellence in scientific inquiry and dissemination. He has been awarded prestigious talent projects such as the New Cornerstone science Foundation and the National Outstanding Youth Science Foundation (NSFC), as well as the Science Exploration Award, Tan Jiazhen Life Science Award (Innovation Award). He received the First Prize in Natural Science of the Ministry of Education's Excellent Achievement Award for Scientific Research in Higher Education (First Completion) and his research was recognized as one of the Top Ten Advances in Life Science in China in 2021.
Prof. Chuan He currently serves as the John T. Wilson Distinguished Service Professor at the University of Chicago, and an Investigator of the Howard Hughes Medical Institute. Prof. He’s research spans a broad range of fields including chemical biology, RNA biology, epigenetics, biochemistry, genomics and has authored or co-authored over 470 publications. He is best known for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation. He was awarded the Paul Marks Prize in Cancer Research (2017), ACS Chemical Biology Lectureship (2019), Ray Wu Award (2022), Wolf Prize in Chemistry (2023), Tetrahedron Prize (2023) and Falling Walls Science Breakthrough of the Year, Life Sciences (2023).
Prof. Xiang-Dong Fu, the Fellow of the American Association for the Advancement of Science, is the Chair Professor at Westlake University. Dr. Fu is a renowned RNA biologist and a leading expert in neuron regeneration. He is credited with co-discovering SR proteins and discovering of a family of kinases specific for SR proteins, which are critical for RNA splicing. Dr. Fu’s research has been centered on understanding the functions of coding and non-coding RNAs in development and disease. His laboratory has also developed multiple technologies for high throughput analysis of gene expression, mRNA isoforms, and genomic interactions. One of their latest breakthroughs is the development of a new cellular reprogramming strategy to generate functional neurons from non-neuronal cells and the application of this approach to reverse the disease phenotype in a Parkinson’s disease model.
Dr. Chengqi Yi is a Boya Professor at School of Life Sciences of Peking University, as well as joint professor at the College of Chemistry and Molecular Engineering. He is also a senior investigator at the Center for Life Sciences between Peking and Tsinghua University and Center for Synthetic and Functional Biomolecules at Peking University. He is a recipient of the National Science Fund for Distinguished Young Scholars and leads major research projects under the Ministry of Science and Technology. Prof. Yi’s research focuses on nucleic acid modifications and their regulatory roles in gene expression. His research interests are chemical biology, epitranscriptomics, and gene editing. His work has demonstrated the unique strengths and advantages of interdisciplinary research
Professor Fuchou Tang is a full professor at BIOPIC, School of Life Sciences, Peking University, and serves as the Associate Director of Beijing Advanced Innovation Center for Genomics (ICG). His lab focuses on the epigenetic regulation of gene expression network during human early embryonic development, germline development and tumorigenesis. His lab is renowned for pioneering the single cell sequencing field and has systematically developed a serial of single cell functional genomic sequencing technologies. With his work being cited more than 20,000 times, Prof. Tang has been recognized as a leading authority in his field and has been invited to present his research at prestigious conferences including AGBT, ISSCR, ICHG, and Gordon Conference, as well as being invited as an editorial board member for esteemed journals such as Cell Stem Cell, Cell Research, Protein & Cell, Genome Biology, Medical Review, Genomics Proteomics & Bioinformatics, Precision Clinical Medicine, and Open Biology.
Professor Xin Li earned his bachelor's degree from Tsinghua University, and his doctoral degree from Cornell University. Subsequently, he completed postdoctoral training at Massachusetts Medical College. Prior to his current position, he served as an Associate Professor at the University of Rochester Medical Center. He has three projects funded by the National Institutes of Health (NIH) and one research project supported by the US Department of Agriculture. His research findings have been published in over 20 top professional journals, including Nature Cell Biology. He has presented his work at nearly 60 international conferences and esteemed universities.
Professor Lingling Chen worked at the Shanghai Institute of Biochemistry and Cell Biology. She has made important contributions to understand the lncRNA diversity, biogenesis and function, in particular, the biogenesis of circular RNAs and their impact on innate immunity, and the roles of lncRNAs in the assembly and function of nuclear bodies. She was selected as a HHMI International Research Scholar in 2017, and as a New Cornerstone Investigator in 2022. Chen serves the community as a member of Editorial Boards including Cell, Science, and Molecular Cell, and as an organizer of meetings including the Annual Meeting of the RNA Society, the CSHL Regulatory & Non-coding RNAs and others. She is the recipient of the LOREAL China for Women in Science Award, the Xplorer Prize, the RNA Society Mid-Career Research Award and others.
Yijun Qi is a Professor in the School of Life Sciences, Tsinghua University and a Senior Investigator at the Tsinghua-PKU Joint Center for Life Sciences. He is also a New Cornerstone Investigator. He is an expert on noncoding RNAs in plants. Work in his laboratory includes identification of new types of small RNAs, investigating the mechanisms of small RNA biogenesis and action in plants and the functions of small RNAs in regulating agronomic traits in crops. He has won a number of prestigious awards including National Innovation Award, National Science and Technology Award (the Second Prize), National Youth Science and Technology Award, and Tan JiaZhen Life Science Innovation Award.
Professor Yujiang Shi, Principal Investigator at IBS, is at the forefront of epigenetics research and has made groundbreaking contributions to the field. He discovered the first histone demethylase LSD1/KDM1A, laying the biochemical and biophysical foundation for histone demethylation, and significantly advancing our understanding of its biological function. Additionally, Prof. Shi has achieved remarkable success in the discovery of the DNA demethylase TET protein family and its functional research in stem cells and cancer, promoting the rapid development of epigenetics. Furthermore, he has made multiple important research achievements in the field of translational medicine for histone and DNA demethylation, with potential applications in clinical practice. Prof. Shi's research output is highly prolific, with over 60 research papers published, including more than 10 in top-tier journals such as Nature and Cell.
Prof. Jin Li, Professor of Genetics at Stanford University, has established himself as a prominent figure in the field of RNA editing research. He obtained a Bachelor's degree in Biology from Tsinghua University in 1997 and a Ph.D. in Biology from Washington University in St. Louis in 2005. Following his doctoral studies, Prof. Li pursued postdoctoral training at Harvard Medical School. His primary research focuses on ADAR enzyme mediated RNA editing and its application in site-specific transcriptome engineering. Prof. Li's groundbreaking work has revealed that the main function of RNA editing is to label endogenous dsRNAs as "self" to avoid being recognized as "non self" by MDA5, which holds significant potential for applications in cancer therapy, autoimmune diseases, and viral infections.
Course Module 2:Neurobiology
Professor Junying Yuan is a globally renowned cell biologist. She is currently the Director of Interdisciplinary Research Center on Biology and Chemistry at the Chinese Academy of Sciences. She is a member of the American Academy of Arts and Sciences since 2007, the American Association for the Advancement of Science since 2010, the National Academy of Sciences since 2017, and the Foreign Members of the Chinese Academy of Science since 2023. She is recognized as a pioneering and influential leader in the field of cell death research. Her transformative discoveries on apoptosis and necroptosis have reshaped our understanding of these processes. Her discovery of mammalian caspases led to a molecular era in apoptosis research. She has found a series of key regulators in apoptosis and necroptosis, and revealed the molecular mechanisms and involvements in human diseases. RIPK1 inhibitors, first discovered and described by Dr. Yuan, have been advanced into human clinical trials for the treatment of human inflammatory and neurodegenerative diseases.
Professor Tak Wah Mak is a famous immunologist, oncologist, and biochemist. He achieved worldwide recognition for his seminal discovery of T cell TCR receptors in 1983, marking a significant milestone in immunology. In 1995, he published a milestone paper on the immune function of immune checkpoint molecule CTLA-4, paving the way for cancer treatment targeting immune checkpoints. He is also the founder of Agios Pharmaceuticals, whose flagship compound IDHIFA ® received FDA approval in August 2017 for the treatment of acute myeloid leukemia, marking the first cancer treatment drug targeting cancer metabolic pathways. He has been selected as a member of the Royal Society of Canada, a member of the Royal Society of London, and a member of the National Academy of Sciences in USA. He has also been honored with a series of internationally renowned awards, including the Behring Price, the King Faisal Price for Medicine, and the Novartis Price in Immunology.
Professor Liqun Luo is a member of the American Academy of Arts and Sciences, and a member of National Academy of Sciences. He is the Ann and Bill Swindells Professor of Humanities and Sciences, Professor of Biology, Professor of Neurobiology at Stanford University, and Investigator of the Howard Hughes Medical Institute. Prof. Luo has dedicated himself to developmental neurobiology research for a long time and is internationally renowned for his work in the field of synaptic branching, which is crucial for the establishment and maintenance of neural circuits. He made significant contributions to the understanding of molecular mechanisms underlying synaptic branching development using fruit flies, and discovered striking similarities between this branching mechanism and the weakening phenomenon observed in mammalian synapses after damage. His remarkable achievements have greatly advanced the fields of neural development, neural network formation, and the technological development of organizational neuroscience.
Professor Yi Rao is the President of Capital Medical University, a Chair Professor and the Founding Director of the PKU-IDG/McGovern Institute for Brain Research at Peking University, the Founding Director of PKU-Tsinghua Center for Life Sciences, and the Founding Director of the Chinese Institute for Brain Research at Beijing. He teaches many courses including neurobiology, genetics, developmental biology, cell biology and pharmacology. He worked on molecular and cellular basis of neural development, revealing the origin of two eyes in a single morphogenetic field, discovering the chemorepellent function of the Slit proteins in axon guidance and neuronal migration, and dissecting signal transduction mechanisms of the chemorepellent Slit and and chemoattractant Netrin. The Rao lab has invented the generally applicable chemoconnectomics approach and generated new genetic resources to study the functional roles of genes and cells in the chemoconnectome (CCT), to manipulate chemical transmission and to map neural circuits. The Rao lab has carried out research with flies, frogs, mice, rats, monkeys and humans to understand fundamental mechanisms both those conserved among animals and those unique for humans.
Professor Qinghua Liu works at the Beijing Institute of Life Sciences, and the Tsinghua University Institute of Biomedical Cross disciplinary Research. He obtained hia Bachelor's degree in Biochemistry from Wuhan University in 1992 and completed his PhD in Biochemistry at Baylor College of Medicine in 2000. Prof. Liu has held positions as an Associate professor at the Southwest Medical Center of the University of Texas in the United States and as a professor at the International Institute of Comprehensive Sleep Medicine at the University of Tsukuba in Japan. His research focuses primarily on the screening of core regulatory genes for sleep and fear and in-depth molecular mechanism research.
Professor Jiayi Zhang is a Professor at the Institutes of Brain Science at Fudan University. She is currently the vice director of State Key Laboratory of Medical Neurobiology. Her work was supported by the One Thousand Talent plan, the National Science Fund for Distinguished Young Scholars and Excellent Young Scholars, Scientific and Technological Innovation 2030, 863 Program, and Shanghai Leading Talent Project. Her work focused on the restoration of vision and motor functions. She utilized inter-disciplinary approaches to develop novel technologies for treating neural disorders, and restored of vision in blind mice using titanium oxide nanowires as artificial photoreceptors, some of them have been advanced into human clinical trials. She won the Shanghai Women's Innovation Newcomer Award at the year of 2020.
Professor Yulong Li obtained his Bachelor’s degree from Peking University and his PhD degree from Duke University, followed by postdoctoral research at Stanford University. He is currently a Professor at the School of Life Sciences at Peking University, the PKU-Tsinghua Center for Life Sciences, and the PKU-IDG/McGovern Institute for Brain Research. His group has developed a series of novel genetically encoded fluorescent sensors, so-called GRAB (GPCR activation based) sensors, for real-time detection of neurotransmitters and neuromodulators, such as ACh, DA, and NE, in vivo. His work has been selected into the Top Ten Progress of Life Sciences in China and the Top Ten News of Medical Science and Technology in China at 2018, the Top Ten Progress of Life Sciences in China and the Top Ten Progress of neuroscience in China at 2023. He has received numerous awards, including the National Science Fund for Distinguished Young Scholars, Scientific Exploration Prize, and the New Cornerstone Science Lab investigator.
Professor Cong Liu received his PhD at Peking University and pursued postdoctoral training at UCLA. He is currently a principal investigator at the Interdisciplinary Research Center on Biology and Chemistry (IRCBC), SIOC, CAS. By combining interdisciplinary chemical and biological approaches. Dr. Liu revealed the structural basis of protein pathological aggregation in neurodegenerative diseases, demonstrated the regulatory mechanisms of protein aggregation by disease-related post-translational modification, developed new strategies of designing small molecules to modulate protein phase separation for therapeutic application. In the past 5 years, as the corresponding or co-corresponding author, Dr. Liu has published over 70 SCI papers, including Cell, Nature Chemical Biology (2), JACS (2), PNAS(6), Nat Struct & Mol Biol (3), Nature Communications (7),Cell Research (5) and Molecular Cell. His systematical findings on protein phase separation and aggregation in neurodegenerative diseases have been well recognized internationally in the field, leading to invitations to contribute review articles to renowned journals such as Cell, Nature Reviews Neuroscience,and Trends in Cell Biology.
Course Module 3:Evolution & Computational Biology
Professor Li Jin is a leading scientist renowned for his groundbreaking contributions to the model of recent African origin of modern humans and the study of human phenomics. His research encompasses genetic structure and migrations of human populations, genetics of human complex diseases and computational biology. He has served as a board member of HUGO, co-founded Genographic Project, Pan-Asian SNP Consortium, and International Human Phenome Consortium (IHPC) , and co-founded National Human Genome Center at Shanghai, Shanghai International Human Phenome Institute. He received numerous well-known awards including State Award of Natural Sciences twice, C.C. Tan Life Science Achievement Award, Distinguished Academic Achievement Award of Human Genome Organization (HUGO), Prize for Scientific and Technological Progress of Ho-Leung-Ho-Lee Foundation.
Professor Mark Stoneking is a geneticist and molecular anthropologist contributing to the field of human evolution. His research interests involve using molecular genetic methods to address questions of anthropological interest concerning the origins, migrations, and relationships of human populations, and the influence of selection during human evolution. He, along with his doctoral advisor Allan Wilson, contributed to the Out of Africa Theory in 1987 by introducing the concept of Mitochondrial Eve, a hypothetical common mother of all living humans based on mitochondrial DNA.
Prof. Axel Meyer is an elected member of the Academy of Europe, the Academia Europaea, German Academy of Sciences Leopoldina, the European Academy of Sciences and Arts, the European Molecular Biology Organization, and the Berlin-Brandenburgische Akademie der Wissenschaften. He has received numerous awards including the Carus Medal from the German Academy of Sciences Leopoldina (2009), the John Simon Guggenheim Memorial Fellowship (1996), the Young Investigator Prize from the American Society of Naturalists, and Hector Science Award 2012. Most recently, he was awarded a Radcliffe Fellowship at Harvard University's Radcliffe Institute for Advanced Study.
Dr. Philip A. Beachy is a world leading developmental biologist. His research interests mainly focus on functional characterization of Hedgehog proteins and other extracellular signals in morphogenesis and in injury repair and regeneration. He also studies the functional roles of various signaling molecules in stem cell physiology and how they can induce cancer stem cells. He discovered how Cyclopamine and Smoothened are related to Itraconazole, thus linking diverse fields of scientific research.
Prof. Katrin Andreasson is a physician-scientist studying mechanisms of immune-mediated brain injury in the Department of Neurology and Neurological Sciences at the Stanford University School of Medicine. She is Co-Director of the Stanford Alzheimer’s Disease Research Center (ADRC) and Co-Director the ADRC Biomarker Core. Her research focuses on the investigation of the cellular and molecular mechanisms of neuronal injury mediated by maladaptive systemic and central nervous system immune responses. She has identified innate immune pathways critical in establishing neurotoxic immune responses that lead to neurodegeneration in models of aging, AD, and stroke.
Professor Chung-I Wu has made numerous contributions in the fields of molecular evolution, population genetics, and evolutionary genomics, particularly in the genetic basis of speciation and natural selection. He has pioneered the study of speciation at the molecular level, introducing cutting-edge gene replacement techniques to answer classical ecological questions in the model organism Drosophila. He also made original contributions in areas such as selfish genes, molecular clocks, X chromosome degeneration, and evolutionary genomics. His proposed hypotheses on the genetic mechanism of reproductive isolation and the gene concept of speciation are innovative and represent a significant departure from traditional ideas in species biology. He has published over 200 papers in top journals like Science, Nature, and PNAS. He has been cited over 20000 times in total and rated as top 100 global scientists in life science by Elsevier. In 2011, he received the second prize of the National Natural Science Award, further solidifying his standing as a leading authority in molecular evolution and genetics.
Professor Manyuan Long has made groundbreaking contributions to the field of evolutionary biology, particularly in the identification of the "Jingwei gene" and elucidating the mechanisms governing new gene formation across various species. His pioneering work in the field of "Origin and Evolution of New Genes" has challenged conventional theories in evolutionary developmental biology and greatly expanded our understanding of gene evolution. His research has been published in top-tier journals such as Nature, Science, Cell, alongside the publication of five books and monographs. His exceptional contributions have been recognized with prestigious awards as the John Simon Guggenheim Memorial Fellowship for Natural Sciences and the Ray Wu Award in 2022, highlighting his leadership and impact in the scientific community.
Professor Xun Gu is a renowned computational molecular evolutionary scientist based at the Department of Genetics at Iowa State University. His research primarily focuses on the development of analytical and statistical methods for evolution and comparative genomics. He has made significant contributions to the field, particularly in the development of a statistical method and bioinformatics software to predict functional differences in protein families. He has conducted statistical analysis of expression differences between duplicate genes, modeled gene changes during genome evolution, and analyzed cross species model organism genomes. Currently, he is exploring new frontiers in systems biology and evolution, with a focus on understanding gene pleiotropy, genetic robustness, genomic complexity, and gene network evolution. He has published over 100 papers and been recognized with the Dupont Young Professor Award in 2011.
Professor Yi Xing is the Francis West Lewis Endowed Chair and Founding Director of the Center for Computational and Genomic Medicine, as well as the Executive Director of the Department of Biomedical and Health Informatics at the Children's Hospital of Philadelphia (CHOP). Prior to his appointment at CHOP and Penn, Dr. Xing was a Professor of Microbiology, Immunology, and Molecular Genetics at UCLA, and served as Program Director of UCLA’s Bioinformatics Interdepartmental Ph.D. Program. Dr. Xing received his BS in Molecular and Cellular Biology and BE in Computer Science and Technology from the University of Science and Technology of China (2001). He completed his PhD training in Bioinformatics with Dr. Christopher Lee at UCLA (2001-2006), and his postdoctoral training with Drs. Wing Hung Wong and Matthew Scott at the Stanford University (2006-2007). Dr. Xing has an extensive publication record in bioinformatics, genomics, and RNA biology. His work has provided fundamental insights into the function, regulation, and evolution of post-transcriptional RNA processing in mammals. His current research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology.
Professor Ting Wang is an internationally recognized geneticist for his research on genetic and epigenetic impact of transposable element on gene regulation. His lab developed widely-used DNA methylomics technologies, and apply integrative methods combining experimental and computational technologies for studying the evolution and adaption of human regulatory networks, particularly on the impact of these processes on human health and disease. His lab is home to the Wash U Epigenome Browser, utilized by various large genomic dataset Consortia including the NIH Roadmap Epigenome Project, ENCODE Project, 4D Nucleome Project, and TaRGET Project. He currently directs the NIH 4D Nucleome Network Data Coordination and Integration Center and the NIEHS Environmental Epigenomics Data Center, and co-lead the latest Human Pangenome project.
Professor Jian Yang’s research focuses on understanding the genomic variations among individuals within and between populations and the links of genomic variations with health outcomes. He has developed a series of software for data analyses in computational biology, including GCTA, SMR, OSCA , etc, which are widely used in the field of human genetics and genomics. He was awarded the Centenary Institute Lawrence Creative Prize (2012), the Australian Academy of Science Ruth Stephens Gani Medal (2015), and the Prime Minister’s Prize for Sciences (2017). Additionally, he has been selected as one of the Clarivate Highly Cited Researchers from 2018 to 2021, underscoring the significant impact of his work in the scientific community.
Professor Yong Zhang has made groundbreaking contributions to the understanding of dynamic evolution of male genes, as well as the role of new genes in early development and their impact on human brain evolution. His achievements represent the forefront of the field. Prof. Zhang has published numerous papers in esteemed journals such as Science, PLoS Biology, Genome Research, etc. Moreover, his work has been cited in reviews on the latest advancements in new gene evolution by renowned publications like Nature Reviews Genetics and Trends in Genetics, attracting significant attention within the academic community.
Professor Robert Kuhn has been instrumental in the development and enhancement of the UCSC Genome Browser, a widely used tool for visualizing and analyzing genomic data. His efforts extend to conducting trainings and workshops on how to use the Browser and its associated bioinformatics tools. Prof. Kuhn's engagement with the medical genetics community has facilitated the acquisition of valuable datasets for the Browser while also providing insights into optimizing its utility for the scientific community. Prof. Kuhn’s contributions have significantly advanced our understanding of genomics and its implications for evolution and health.
Professor Shuhua Xu is a Professor of human population genetics, Principal Investigator of the Population Omics Group, and Director of the Center for Evolutionary Biology at Fudan University. He was appointed as a Max-Planck Independent Research Group Leader in 2011, and was supported by both Max-Planck and CAS from 2012 to 2018. Currently, Prof. Xu holds a Distinguished Professorship at Fudan University and a Distinguished Adjunct Professorship at ShanghaiTech University in China. The Population Omics Group led by Dr. Xu is using computational approaches and developing new methods to dissect the genetic architecture of human populations, quantitatively characterize their admixture features, and reveal their migration history and adaptive divergence. Prof. Xu has authored numerous scientific papers published in prestigious journals such as Nature, Science, Cell, PNAS etc. Additionally, he serves as the co-Editor-in-Chief of Molecular Genetics and Genomics.
序号 | 专家姓名 | 所在单位 | 课程模块 | 简介 |
1 | Jerry L. Workman 院士 | 斯托瓦斯研究所 | RNA生物学 | 开创性的科学家,通过揭示组蛋白在DNA包装成染色质和基因表达调控中的关键作用,在基因表达研究领域做出了重大贡献。 |
2 | Dinshaw J. Patel 院士 | 美国纪念斯隆-凯特琳癌症中心 | RNA生物学 | 著名结构生物学家,研究大分子识别的结构生物学,包括RNA催化、RNA干扰和DNA损伤的旁路。 |
3 | Don Cleveland 院士 | 加州大学圣地亚哥分校 | RNA生物学 | 著名肿瘤学和神经生物学家,在有丝分裂纺锤体的组装和染色体运动的调控方面做出了开创性的贡献。 |
4 | 高绍荣院士 | 同济大学 | RNA生物学 | 国际知名干细胞与发育生物学家,证明了诱导多能干细胞的多能性,成功解码早期胚胎和体细胞核移植胚胎的多层级表观修饰重塑动态,解析胚胎重编程与分化的重要表观调控机制。 |
5 | 潘多加院士 | 得克萨斯大学 | RNA生物学 | 世界知名的细胞与发育生物学家,系统解析了Hippo信号通路的关键分子成分。 |
6 | 徐彦辉研究员 | 复旦大学 | RNA生物学 | 围绕基因启动子区发生的转录起始复合物装配,染色质重塑和DNA甲基化调控,系统揭示了基因表达调控的分子机制。 |
7 | 何川教授 | 芝加哥大学 | RNA生物学 | 是“RNA表观遗传学”领域的发起人之一,发现了可逆RNA甲基化及其在基因表达调控中的作用。 |
8 | 付向东教授 | 西湖大学 | RNA生物学 | 国际顶尖的RNA生物学家和神经再生领域专家,长期专注于编码和非编码RNA的调控机制的研究,并且创新性开发了多项相关技术。 |
9 | 伊成器教授 | 北京大学 | RNA生物学 | 致力于核酸修饰对基因表达的调控研究,开拓了中国科学家主导的表观转录组学新领域,并获得了一系列具有自主知识产权的新技术。 |
10 | 汤富酬教授 | 北京大学 | RNA生物学 | 在国际上率先系统发展了单细胞功能基因组学研究体系,开启了单细胞转录组测序时代。 |
11 | 李鑫教授 | 浙江大学 | RNA生物学 | 专注于胞质内RNA命运调控的机理研究——为什么某些RNA的稳定性比其它RNA高出一千倍,某些RNA被高效翻译,而其他RNA不被翻译。 |
12 | 陈玲玲研究员 | 中国科学院 | RNA生物学 | 发现sno-lncRNA、环形RNA等新家族,揭示它们的生成加工降解途径、重要生物学功能以及良好转化应用前景。 |
13 | 戚益军教授 | 清华大学 | RNA生物学 | 从事植物中RNA调控机制和功能研究,取得系统性原创成果,包括阐明植物小RNA通路机制,发现diRNA等三类新型小RNA,揭示小RNA对作物农艺性状的调控等。 |
14 | 石雨江教授 | 复旦大学 | RNA生物学 | 主要从事表观遗传学前沿研究并作出了开创性贡献:发现了第一个组蛋白去甲基化酶LSD1/KDM1A,开创并奠定了组蛋白去甲基化的生物化学与生物物理学基础,并对其生物学功能的阐明作出了关键性的贡献。 |
15 | 李进教授 | 斯坦福大学 | RNA生物学 | 发现RNA编辑的主要功能是将内源性dsRNAs标记为“自我”,这在多种疾病中有潜在应用价值。 |
16 | 袁钧瑛院士 | 中国科学院 | 神经生物学 | 世界知名的细胞生物学家,开创了两个主要的细胞死亡研究领域,包括细胞凋亡(apoptosis)和细胞坏死(necroptosis)。 |
17 | Tak Mak院士 | 多伦多大学 | 神经生物学 | 世界知名的免疫学基因和癌症基因领域专家,首次发现T细胞TCR受体,并在免疫学方面做出多项开创性工作。 |
18 | 骆利群院士 | 斯坦福大学 | 神经生物学 | 在神经发育、神经网络的构建与组织神经科学的技术开发方面做出了卓越贡献,突触分枝以建立和维持神经回路领域的研究处于国际领先水平。 |
19 | 饶毅教授 | 北京大学/首都医科大学 | 神经生物学 | 发现两个眼睛在发育中来源于同一形态发生场、发现Slit 为神经导向蛋白质、提出体细胞运动共同分子机理、发现争斗的中枢和外周机理、求偶的分子控制。 |
20 | 刘清华研究员 | 北京生命科学研究所 | 神经生物学 | 通过经典的生化分离纯化和体外重组手段,为揭示Dicer和RISC复合体的分子机理做出了一系列重要贡献。 |
21 | 张嘉漪研究员 | 复旦大学 | 神经生物学 | 开发了纳米线阵列人造光感受器,使失明动物恢复了一定时间和空间分辨率的视觉,已开展多例临床实验。 |
22 | 李毓龙教授 | 北京大学 | 神经生物学 | 建立了一系列新型遗传编码的神经递质荧光探针,可实时、定量研究神经递质的释放在生理及病理作用下的重要作用。 |
23 | 刘聪研究员 | 中国科学院 | 神经生物学 | 提出蛋白聚集体结构多态性决定病理毒性的观点,阐释化学修饰多维调控蛋白病理聚集的机制,发展靶向病理蛋白聚集的化学小分子抑制剂及示踪剂。 |
24 | 金力院士 | 复旦大学 | 进化与计算生物学 | 近代人类非洲起源模型和人类表型组学研究的领先科学家。对第二代遗传标记的群体遗传学理论和方法、连锁不平衡形成机制及其在疾病基因定位中的应用等领域做出了重要贡献,并在东亚人群的遗传结构、群体分化、迁徙路线、人群混合和环境适应等方面的研究取得了重大成果。 |
25 | Mark Stoneking 院士 | 马克斯·普朗克进化人类学研究所 | 进化与计算生物学 | 德国著名的遗传学家和分子人类学家,对人类进化领域做出杰出贡献。 |
26 | 吴仲义院士 | 中山大学 | 进化与计算生物学 | 率先在遗传学实验的基础上把物种形成研究带入分子层次,首先在模式动物果蝇的研究中引入尖端基因取代技术来解答生态学问题。同时在自私基因、分子钟、X染色体退化及进化基因组学等领域的研究也取得了独创性成果。 |
27 | Robert Kuhn 教授 | 加州大学圣克鲁斯分校 | 分子遗传学 | 主导开发了UCSC基因组浏览器(UCSC Genome Browser),用于基因组数据分析与可视化,在基因组研究领域应用广泛,其极大地促进了我们对于基因组及其进化与医学意义的理解。 |
28 | 龙漫远教授 | 芝加哥大学 | 进化与计算生物学 | 在基因组演化研究方面有很深的造诣,特别是在新基因的起源、性基因的演化等研究领域取得了多项突破性成果,发现了第一个年轻基因-精卫基因。 |
29 | 谷迅教授 | 爱荷华州立大学 | 进化与计算生物学 | 计算分子进化著名学者,开发了预测蛋白质家族功能差异的统计方法和生物信息学软件,并分析跨物种模式生物基因组。 |
30 | 邢毅教授 | 宾夕法尼亚大学 | 进化与计算生物学 | 在生物信息、基因组学和RNA领域有着杰出贡献。他的研究为哺乳动物中转录后RNA加工过程的功能、调节和进化提供奠基性基础。 |
31 | 王艇教授 | 圣路易斯华盛顿大学 | 进化与计算生物学 | 开发了广泛使用的DNA甲基组学技术,并应用结合实验和计算技术的综合方法来研究人类调节网络的进化和适应,特别是这些过程对人类健康和疾病的影响。 |
32 | 杨剑教授 | 西湖大学 | 进化与计算生物学 | 其团队开发的GCTA、SMR、OSCA等计算生物学分析软件已在人类遗传学和基因组学研究领域广泛应用 |
33 | 张勇研究员 | 中国科学院 | 进化与计算生物学 | 在基因组水平雄性基因的动态进化、新基因在早期发育中的作用以及新基因对于人类大脑进化的作用等方面都取得了具有突破意义的成果,刷新了学术界的认识 |
34 | 徐书华教授 | 复旦大学 | 进化与计算生物学 | 长期致力于人类群体基因组学研究,发展和运用群体基因组学方法和计算生物学手段,将群体遗传学和分子进化理论应用于适应性演化和疾病发生机制研究;组织和推动了中国人群泛基因组联盟(CPC)、汉族十万人基因组计划(Han100K)等大型群体基因组学研究项目 |
35 | Axel Meyer 院士 | 康斯坦茨大学 | 进化与计算生物学 | 长期从事非洲慈鲷鱼(cichlid fish)的进化分化,鱼类特异性基因组复制,脊椎动物的分子系统发育,以及生态选择和性选择在物种形成中的作用等方向研究。在动物学、系统发育学、进化发育生物学、分析进化和比较基因组学等领域发表了超过400篇论文,H-index 120,总引用率超过66000次。 |
36 | Philip A. Beachy 院士 | 斯坦福大学 | 进化与计算生物学 | 国际顶尖的发育生物学家,对Hedgehog信号通路的研究有着很深的造诣。40多年来的科研历程,从Hedgehog基因的克隆到针对Hedgehog信号通路靶向药物的问世,无数个第一次的发现让Philip A. Beachy教授在国际上享有很高的赞誉 |
37 | Katrin Andreasson 教授 | 斯坦福大学 | 进化与计算生物学 | 长期从事由适应不良的全身和中枢神经系统免疫反应介导的神经元损伤的机制研究,确定了先天免疫通路会在衰老,阿尔兹海默症和中风疾病模型中通过建立神经毒性免疫反应导致神经退行性病变。 |